SNCA and Parkinson disease: For example, in PD, several disease-associated mutations in alpha-synuclein, PINK, Parkin, and LRRK2 have been shown to impact fusion/fission regulators or exert their effects directly by binding to the mitochondrial membrane (Yang et al., 2008; Glauser et al., 2011; Wang et al., 2012; Pozo Devoto et al., 2017).