Kin et al.’s initial and follow-on studies identified that recovery of the available NAD+ pool by administration of Dunnione an antifungal and anti-tumor drug that is a substrate of antioxidant flavoprotein NADH: quinone oxidoreductase 1 (NQO1) ameliorated the ototoxic effects of cisplatin (Kim et al., 2014, 2016). This evidence concerns the gene NQO1 and neoplasm.