The top hub genes, including CXCL1, CXCL2, CXCL8, IL1β, and PTGS2, might be regulated by microRNAs being involved in TNF-α/IL-1β treated annulus cells, providing a guideline for diagnosis and treatment for degenerative disc disease. Here, CXCL8 is linked to intervertebral disk degenerative disorder.