TGM4 and peeling skin syndrome: Other research studies demonstrated that TGP monotherapy in pSS was effective [11, 12], and co-administration of TGP with an immunosuppressant (IS) showed superior therapeutic efficacy than IS alone [13], which mainly manifested in ameliorating sicca symptoms, reducing the local concentration of autoantigens, and decreasing the serum level of inflammatory cytokines [11, 12, 14].