In addition, by applying forward genetic screens of mutations or overexpression constructs, this model can be expanded to discover novel genes that drive glial neoplasia and to elucidate other downstream players in the EGFR and PI3K pathways that act as “enhancers,” which produce a worse GBM phenotype, or “suppressors,” which ameliorate the GBM phenotype (Read et al., 2013). The gene discussed is EGFR; the disease is glioblastoma.