Knocking out both the IL10RA and IL2RG genes via a CRISPR/Cas9 approach in primary CD8+ T cells markedly impaired their proliferation relative to that of CD4+ T cells when compared to CD8+ T cells treated with a non-targeting sgRNA (Supplementary Figure 2B), suggesting that CD4-derived IL-2 and IL-10 may play an important role in sustaining BsAb-mediated CD8+ T cell proliferation and tumor cell killing. Here, CD4 is linked to neoplasm.