Suppression of GSDMD expression in gastric cancer can activate the signal transducer and activator of transcription 3 (STAT3) and phosphatidylinositol 3 kinase/protein kinase B (PI3K/PKB) signaling pathways and regulate cell cycle-related proteins to accelerate the S/G2 phase cell transition (62). This evidence concerns the gene PIK3CA and gastric cancer.