In accession to exploring the possibility that drugs with proven clinical applications such as artemisinin and rapamycin exert protective effects in sepsis through ferroptosis, other ferroptosis inhibitors such as punicalagin inhibiting Nrf2 and sulfasalazine affecting the Xc- system and GSH synthesis also showed great therapeutic effects in sepsis have been validated accordingly, but whether their mechanism of action is related to the control of ferroptosis remains to be explored (133, 134). The gene discussed is NFE2L2; the disease is Sepsis.