SLC7A11 and colorectal cancer: IMCA induces ferroptosis in colorectal cancer cells by downregulating SLC7A11 expression via the AMPK/mTOR pathway, thereby inhibiting cystine transport, reducing GSH synthesis, and promoting reactive oxygen species accumulation (69).These regulatory mechanisms were also validated by Yuchao Gu and colleagues through unbiased proteomic screening of xCT binding chaperones as well as functional validation (70).