This is clearly demonstrated in Figure 6 that shows that in our study cohort: a) most heavy alcohol consumers display TLR9high tumors (as shown previously in Figure 3); b) those TLR9high tumors that belonged to heavy alcohol consumers presented significantly fewer CD8+ T cells in the tumor center compared to those TLR9high tumors from low alcohol consumers and c) tumors from low alcohol consumers develop tumors with CD8+T cells that are distributed homogeneously between the invasive margins and in the center of the tumor, independently of TLR9 expression. The gene discussed is CD8A; the disease is neoplasm.