While loss of catalytic activity of TET proteins is strongly associated with hematopoietic stem cell hyperproliferation and myeloid malignancies (12, 46, 91), it has been recently suggested that the enzymatic activity of TET2 might be dispensable for its tumor suppressive role at least in some lymphoid malignancies (48) as well as in the context of inflammation (49). The gene discussed is TET2; the disease is myeloid neoplasm.