The main findings in this study of folic acid-induced renal fibrosis in mice are as follows: (1) LNA-anti-miR-150 ameliorated renal interstitial fibrosis at day 30 after the folic acid injection, (2) LNA-anti-miR-150 reduced the renal infiltration of total macrophages and pro-inflammatory polarized CD11c+ M1 and CD206+ M2 macrophages, and (3) LNA-anti-miR-150 regulated the protein expression of the SOCS1/JAK1/STAT1 pathway proteins. Here, SOCS1 is linked to renal fibrosis.