The RA risk SNP (rs28411362) forms a 3D contact with the MTF1 promoter during inflammatory factor-stimulated chromatin remodeling of RA FLS, whose binding motif stimulates FLS recruitment, and MTF1 inhibition significantly suppresses FLS cytokine and chemokine production and improves the mouse arthritis model (73). Here, MTF1 is linked to arthritic joint disease.