Furthermore, two modules of macrophages (Module2: highly expresses RNASE1, C1QA, CD163, CD14, C1QC, FCGRT, and MS4A7; Module10: highly expresses APOC1, CTSB, CTSL, and TYROBP), which exhibited the characteristics of TAMs, increased significantly in keloid. The gene discussed is CTSB; the disease is keloid.