In addition, loss of Id2 expression is associated with increased MLL-AF9-induced leukemia in mice, and over expression of Id2 inhibits the growth of MV4-11 and MOLM-13 AML cell lines that express MLL-AF9, and Kasumi AML cells that express AML-ETO (122). The gene discussed is MLLT3; the disease is acute myeloid leukemia.