Moreover, the frequency of other extrahepatic autoimmune diseases, such as Sjogren’s syndrome (SS) and rheumatoid arthritis (RA), was higher in DRB1*04:05 positive patients than in DRB1*04:05 negative patients (36.4% vs. 7.7%, P=0.007). The gene discussed is HLA-DRB1; the disease is Sjogren syndrome.