Since the TNF-α-308 AA genotype is more predominant in erosive OLP and more keratinocyte apoptosis is observed in patients with erosive OLP, it can be inferred that the TNF-α-308 AA genotype leads to a higher production of TNF-α, which promotes CD8+ cytotoxic T cell-induced apoptosis in keratinocytes in OLP lesions (47). This evidence concerns the gene TNF and oral lichen planus.