Although the immune escape strategies in lymphoma may vary between individuals (119), the most significant known stimuli so far related to the pathogenesis of B-cell lymphoma in APDS are related to the upregulation of the mTOR signaling pathway with the downstream effector of PI3K/AKT, increased production of transcription factors involved in the process of apoptosis, affecting the regulation of the cell cycle conducting to uncontrolled cell survival and malignant transformation (120, 121). This evidence concerns the gene PIK3CD and activated PI3K-delta syndrome.