Our data show that up to one-fifth of NHL patients had similar CVID-related genetic pathogenic variants in the somatic line, some with a frequency up to 6%, as is the case of PIK3CD. Several of these genes were significantly associated with different important pathways of the immune response, inflammation, and cell repair (45, 50, 56, 98, 136). This evidence concerns the gene PIK3CD and non-Hodgkin lymphoma.