PIK3CD and lymphoma: Although the immune escape strategies in lymphoma may vary between individuals (119), the most significant known stimuli so far related to the pathogenesis of B-cell lymphoma in APDS are related to the upregulation of the mTOR signaling pathway with the downstream effector of PI3K/AKT, increased production of transcription factors involved in the process of apoptosis, affecting the regulation of the cell cycle conducting to uncontrolled cell survival and malignant transformation (120, 121).