CCR2 and Hepatic fibrosis: In the progression of liver fibrosis, monocytes are recruited to the site of injury and aggravate inflammatory responses, which is regulated by chemokines and their receptors in mouse models and human diseases, including CCL2-CCR2, CCL1-CCR8, CCL5-CCR1/CCR5, as well as CXCL10-CXCR3 (39).