By performing the univariable Cox survival analysis of 115 NRGs in the ICGC-LIRI-JP dataset, nine critical genes (CHRNA3, GABRR2, GRM2, CHRNG, GRIA2, GRM6, GRIN2B, ADRA2C, and GRID2), which were significantly correlated with the OS of the patients with HCC, were identified (Figure 2A). This evidence concerns the gene GRM2 and hepatocellular carcinoma.