Chung et al. (2011) found that GRIN2B hypermethylation was more frequent in invasive pulmonary adenocarcinoma, which indicated that GRIN2B dysfunction might facilitate tumor invasion. Park et al. (2011) showed that the promoter CpG island methylation of GRIN2B changed significantly during breast cancer progression. The gene discussed is GRIN2B; the disease is neoplasm.