The plasma membrane GRP78 has been uncovered in various human cancers, including leukemia (Staquicini et al., 2018), melanoma (de Ridder et al., 2011), prostate cancer (Arap et al., 2004), and colorectal cancer (Shin et al., 2003; Li et al., 2013). Here, HSPA5 is linked to colorectal cancer.