Jiang et al. (2019) constructed GRP78-targeted nanocage to specifically target and kill hepatocellular carcinoma and suppress lung metastasis. Here, we cloned Pep42, a cyclic oligopeptide that specifically targets cell surface GRP78, into a second-generation CAR construct to generate GRP78-CAR and demonstrated that GRP78-CAR T cells can effectively induce cytotoxicity of AML cells in vitro and eradicate explanted leukemia cells in vivo. Here, HSPA5 is linked to leukemia.