HK1 and major depressive disorder: Second, combined with network pharmacology and molecular docking techniques, the potential active components, targets, and related metabolic pathways of ASH in the treatment of depression were predicted, that is, isofraxidin, quercetin, kaempferol, and acacetin might target DAO, MAOA, and MAOB to regulate glycine, serine, and threonine metabolism, while eleutheroside B1 and eleutheroside C seemed to regulate starch and sucrose metabolism by targeting GAA, HK1, and PYGM.