NPM1 and acute myeloid leukemia: The most frequently reported genetic abnormalities in AML affect the fms like tyrosine kinase 3 (FLT3), nucleophosmin (NPM1), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 1 or 2 (IDH1, IDH2), Neuroblastoma RAS viral oncogene homolog/Kirsten rat sarcoma viral oncogene homolog (NRAS/KRAS), runt-related transcription factor 1 (RUNX1), Tet methylcytosine dioxygenase 2 (TET2), p53, CCAAT/enhanced binding protein α (CEBPA), and/or mixed-lineage leukemia (MLL) genes (Falini et al., 2005; Marcucci et al., 2011; Ferrara and Schiffer, 2013; Ley et al., 2013).