Inhibition of HH signaling using cyclopamine, GANT61, recombinant HHIP or anti-hedgehog neutralizing antibodies resulted in increased apoptosis, reduced proliferation, and restored chemosensitivity to cytarabine of CD34+ but not CD34− leukemic cell lines or primary AML cells (Kobune et al., 2009; Long et al., 2016). This evidence concerns the gene HHIP and acute myeloid leukemia.