Due to seminal work showing that the LHb is a key regulator of negatively motivated behavior (Matsumoto and Hikosaka, 2007, 2009a,b; Jhou et al., 2009) and more recent evidence of efficacy as a therapeutic target for major psychiatric disorders (Yang et al., 2008; Li et al., 2011, 2013), the number of scientific publications is now growing steadily at about 8% per year. This evidence concerns the gene LHB and psychiatric disorder.