SLC1A2 and Parkinson disease: Functional changes in the glial glutamate transporter GLT-1, which tightly regulates extracellular glial glutamate transmission, were found to modulate the firing rate of LHb neurons and elicited depressive-like phenotypes in rodents (Cui et al., 2014; Kang et al., 2018; Aizawa et al., 2020; Figure 6C), and a more recent study found downregulation of GLT-1 in the LHb after lesioning the substantia nigra pars compacta (SNc) in a rat model of Parkinson’s disease (PD) (Lyu et al., 2021).