GSTM1 and major depressive disorder: Consistent with a role as an anti-reward center, growing evidence now suggests that the hyperactivation of Hb, as a major component of networks, is one of the typical pathophysiological observations involved in the pathogenesis of depression, autism, schizophrenia, and drug abuse (Fakhoury, 2017; Cui et al., 2018; Yang et al., 2018; Buhler and Carl, 2021).