Several studies in this review [24-28], found that diets defined as “poor” in quality (diets with low intake of fish, shellfish, whole grains, fruits, and vegetables and high intake of smoked meats and sweets), diets with higher dietary inflammatory index (DII) scores, diets with low adherence to the Anti-inflammatory Diet in Rheumatoid Arthritis (ADIRA) protocol, or diets with low adherence to the Mediterranean diet are associated with poorer outcomes including higher CRP and ESR levels and increased pain levels. The gene discussed is CRP; the disease is rheumatoid arthritis.