Inhibited proliferation, migration and invasion of RA fibroblast-like synoviocytes in vitro, significantly decreased TNF-α-induced increases in the mRNA levels of MMP-2, MMP-3, MMP-8, and MMP-9; as well as the proinflammatory factors IL-6, IL-8, and IL-1β. This evidence concerns the gene TNF and rheumatoid arthritis.