CRP = c-reactive protein; DAS = disease activity score; ESR = erythrocytes sedimentation rate; IL = interleukin; MMP = matrix metalloproteinases; PUFAs = polyunsaturated fatty acids; RA = rheumatoid arthritis; RCT = randomized control trial; TNF-α = tumor necrosis factor alpha; HOMA-b = homeostatic model assessment of beta-cell function; HOMA-IR = homeostatic model assessment of insulin resistance. The gene discussed is TNF; the disease is rheumatoid arthritis.