Weight, BMI, and waist circumference correlated with the activity of RA and the concentrations of CRP and ESR went up in tandem with BMI (r=0.36 and 0.31; p<0.01); asymmetric dimethylarginine but not nesfatin-1 (adipokines), was associated with increased BMI and disease activity in RA patients; higher protein intake correlated to higher CRP and ESR while higher carbohydrate intake correlated to higher CRP and lower nesfatin-1 levels. The gene discussed is NUCB2; the disease is rheumatoid arthritis.