Cytokines including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1B, IL-6, IL-17, and IL-18, as well as inflammatory markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) that have been used in diagnosing and tracking the progression of RA [11-12]. This evidence concerns the gene IL6 and rheumatoid arthritis.