By stimulating the Hippo signaling system, DIM slowed the growth of gastric cancers in a xenograft mouse model, according to Li et al. Reduced synthesis of CDKs (cyclin-dependent kinases) 2, 4 and 6, as well as cyclin D1, allowed for G1 cell cycle arrest while increasing levels of p53 protein (132). This evidence concerns the gene TP53 and gastric cancer.