When the anti-apoptotic Bcl-2 and xL proteins, as well as proteins associated with B-cell lymphoma 2 (Bcl-2), are inhibited and pro-apoptotic proteins like p21, p27, and p53 are activated, hepato-pancreatic cancer cells might undergo apoptosis (149, 178). Here, TP53 is linked to familial pancreatic carcinoma.