Resveratrol (0.5 or 1.0 g) was sufficient to provide anticarcinogenic effects in colon cancers by reducing tumor cell proliferation by 5% (P < 0.005) (387) Furthermore, in nine patients with colon cancer and liver metastases, a daily injection of 5 g micronized resveratrol resulted in a 39% rise in cleaved caspase-3, a marker of apoptosis (388). The gene discussed is CASP3; the disease is colonic neoplasm.