BAX and colonic neoplasm: Showcase of Mexican oregano in colon cancer cells, there was an increase in the expression of BAX (apoptotic protein) and a decrease in the expression of Bcl-2, PARP, and Survivin (anti-apoptotic proteins), as well as an increase in the expression of caspase-3 in various oregano cultured plants (wild type, in vitro and ex vitro plant tissue culture) (202).