Rosemary has been shown to have significant antiproliferative activity against several human cancer cell lines (266–269), induce apoptosis via nitric oxide production (270, 271), antioxidant activity (265, 266, 272), decreased TNF-α, IL-6, and COX2 levels (273, 274), suppress lipid peroxidation (261, 275, 276), prevent carcinogen-DNA formation (265), stimulation of p53 and BAX (277), reduction of Bcl-2, Mdm2, and Bcl-xL expression, and stimulation of caspase-3 and -9 expression (272, 274, 277, 278). Here, TP53 is linked to cancer.