Although resveratrol suppresses tumor cell proliferation by activation of proapoptotic proteins (P21 and P53) and suppression of hippo–YAP, inhibition of MAPK, phosphoinositide 3-kinase (PI3K)/Akt, nuclear factor β (NF-β), activating protein-1 (AP-1) HIF-1α and signal transducer and activator of transcription 3 (STAT3) (325–327). This evidence concerns the gene PIK3CA and neoplasm.