Carvacrol significantly slowed the growth, migration, and invasion of colon cancer cells by stopping cells at the G2/M phase and causing them to die, reduced Bcl-2 expression, phosphorylated extracellular regulated protein kinase (p-ERK) and p-Akt, and increased BAX and c-Jun N-terminal kinase (p-JNK) expression (LoVo and SW620 metastatic cells line) (213). This evidence concerns the gene BAX and malignant colon neoplasm.