Such as in vitro study on human CRC cells HCT116 and SW620, the results indicated that RV dose-dependently upregulated the expression of several proapoptotic proteins such as BAX, cytochrome c, cleaved caspase-9, and caspase-3, while anti-apoptotic protein Bcl-2 expression levels was reduced in RSV-treated CRC cells. Here, CASP9 is linked to colorectal carcinoma.