Previous studies have also shown that p70S6K induces insulin resistance via phosphorylation of serine residues (Ser-302/307, Ser-307/312, Ser-632/636, and Ser-1097/1101) of the insulin receptor subtract 1 and subsequent attenuation of the PI3K/AKT pathway (29). The gene discussed is RPS6KB1; the disease is Insulin resistance.