Finally, we demonstrated that BCPs treatment significantly changed the mRNA and protein levels of PPARα, LCAT, CPT1, and EPT1 in the glycerophospholipid metabolism signaling pathway, which might be the underlying mechanisms involving BCPs treatment to alleviate obesity through reshaping gut microbiota and improving lipid metabolism disorders. This evidence concerns the gene SELENOI and obesity due to melanocortin 4 receptor deficiency.