In the liver, the mRNA expression level of peroxisome proliferator-activated receptor alpha (PPARα), lecithin:cholesterol-acyl-transferase (LCAT), carnitine palmitoyltransferase 1 (CPT1), and phospholipase D1 (PLD1) were significantly up-regulated, whereas the mRNA expression of ethanolamine phosphotransferase 1 (EPT1) and lysophosphatidylcholine acyltransferase 2 (LPCAT2) was down-regulated in the BC group and LS+BC group compared to the HFD group (Figure 9A). The gene discussed is LCAT; the disease is breast cancer.