The common genes included SGCD, BIRC7, HAVCR1, DHRS9, HELQ, DMRT1, SVOPL, DZANK1, LUZP2, MCMDC2, ESCO2, and CSF2. Most of these genes may be associated with the response of the heart to HE. The gene discussed is ESCO2; the disease is hereditary elliptocytosis.