This association is due to the role of HSF1 in activating pathways such as protein kinase C (PKC) [11], nuclear factor-kappaB (NF-κB) [12], phosphoinositide 3-kinase (PI3K), Akt/mammalian (or mechanistic) target of rapamycin (mTOR) [8], which are essential for proliferation, resistance to apoptosis, migration, invasion, and cancer cell metastasis [8, 10, 13, 14]. The gene discussed is NFKB1; the disease is cancer.