PGR and benign neoplasm: GnRH-a, as one of the drug treatments for uterine fibroids, was observed to cause shrinkage in fibroids size and reduction of blood supply in fibroids (13, 25).It has been proven the crucial part that estrogen/progesterone receptor (ER/PR) expression plays in the development of UFs, which are benign tumors dependent on ovarian hormones (26, 27).