CACNA1C and schizophrenia: Several GWAS studies have also identified the CACNA1C gene polymorphism (rs1006737) as a susceptibility locus for schizophrenia (81) which often comes with alterations in prefrontal activation and fronto-hippocampal connectivity during emotional processing and executive cognition (82, 83) and finally lead to poor working memory performance (84, 85), especially impact on the encoding phase of working memory (86).