Univariate Cox analysis revealed that history of chronic lung disease, the presence of septic shock, use of mechanical ventilation, baseline heart rate, respiratory rate, mean atrial pressure, GCS, APACHE II score, SOFA score, site of infection, pH, lactic acid, BUN, creatinine, albumin, fibrinogen, and AFR were probable valuable prognostic factors in septic patients. The gene discussed is ALB; the disease is infection.