In in vivo studies, resveratrol ameliorated RA through activation of the Nrf2-ARE signaling pathway via the SIRT1/NF-κB/miR-29a-3p/Keap1 and SIRT1/NF-κB/miR-23a-3p/cul3 signaling pathway [33]. Here, NFKB1 is linked to rheumatoid arthritis.