We do not contend that these specific CGRP SNPs are the only ones that could produce similar findings given that another study to explore the role of CALCA and RAMP1 genes on migraine found no significant associations of CALCA or RAMP1 on their headaches; albeit with different SNPs for CALCA (rs3781719, rs145837941) and RAMP1 (rs3754701, rs7590387) used in their analyses (45). This evidence concerns the gene RAMP1 and Headache.