On the other hand, IGFBP1 is a protein-coding gene similar to IGFBP2. It has been shown that IGFBP1, a downstream protein of Jagged1, is related to the severity of coronary atherosclerosis among elderly patients, and aging-linked expression elevation in circulating IGFBP1 might be an adaptive response to counteract HCAEC aging via the Akt signaling pathway (51). This evidence concerns the gene JAG1 and coronary atherosclerosis.