CPPS: chronic pelvic pain syndrome; CRP: C-reactive protein; GUPI: genitourinary pain index; IPSS: International Prostate Symptom Score; NIH-CPSI: National Institutes of Health-Chronic Prostatitis Symptom Index; PDI: Pain Disability Index; PFSD: Pain Frequency-Severity-Duration; RAND-36: RAND corporation 36-Item Short Form Health Survey; VAS: visual analog scale. The gene discussed is CRP; the disease is prostatitis.