MKI67 and obesity due to melanocortin 4 receptor deficiency: To investigate whether there are statistically significant differences in the proliferation of index Ki67 between the two groups, a Wilcoxon Rank Sum test was used; the median in the group with obesity was 30 and in the group without obesity was 25, p-value = 0.9661, Difference (CI 95%)=5.00 (-15.00 to 10.00). The observed differences are not statistically significant (p> 0.05).