To assess the association of obesity and elevated serum leptin values with tumor subtypes with an unfavorable prognosis, the groups of patients surveyed in this study were divided into two groups: group A in which patients with luminal tumors were included (luminal A and luminal B) and group B (HER2 positive and triple-negative tumors). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.