MAPT and Alzheimer disease: Tau has been implicated in facilitating hyperexcitability in mouse models of AD as well as models of epilepsy (Palop et al., 2007; Roberson et al., 2007, 2011; Ittner et al., 2010; Peters et al., 2020), and it is possible that VGlut1-pHluorin intensity in tauP301L pos mice may change as a function of neuronal stimulation.