Importantly, neither cognitive deficits nor the increase in glutamate release and VGlut1 levels were observed in the rTg(TauWT)21221 mouse model that expresses wild-type 4R0N human tau at concentrations equivalent to P301L human tau in tauP301L pos mice, but without the P301L mutation and associated tau pathology (Hunsberger et al., 2014). Here, SLC17A7 is linked to Cognitive impairment.