This early increase in VGlut1 in MCI patients may help explain the hippocampal hyperexcitability that is predictive of the degree and rate of cognitive decline, as well as the conversion to AD, that has been previously observed in MCI patients (Mackenzie and Miller, 1994) and (see Toniolo et al., 2020 for review). Here, SLC17A7 is linked to Alzheimer disease.