NUMB and breast cancer: It has been reported that NUMB PRRL promotes cell proliferation while NUMB PRRS directs cell differentiation.19 Besides, NUMB PRRL increases the proliferation and metastasis of liver and breast cancer, while NUMB PRRS inhibits these phenotypes.20,21 The inclusion of skipping exon of NUMB (NUMB PRRL) was significantly increased in LUAD compared to adjacent-normal tissues (Fig. 1h).