STAT3 and cancer: Interestingly, the DKC1 gene was negatively correlated with the IC50 value of GSK319347A, a dual inhibitor of TBK1 and IKKε, and the PDIA4 gene was negatively associated with the IC50 value of Pyrimethamine, a STAT3 inhibitor displaying anti-cancer and immune-stimulatory effects,24 suggesting that the high expression of DKC1 and PDIA4 in LUAD may increase the sensitivity of GSK319347A and Pyrimethamine, respectively (Fig. 2c, d).