Interestingly, the DKC1 gene was negatively correlated with the IC50 value of GSK319347A, a dual inhibitor of TBK1 and IKKε, and the PDIA4 gene was negatively associated with the IC50 value of Pyrimethamine, a STAT3 inhibitor displaying anti-cancer and immune-stimulatory effects,24 suggesting that the high expression of DKC1 and PDIA4 in LUAD may increase the sensitivity of GSK319347A and Pyrimethamine, respectively (Fig. 2c, d). This evidence concerns the gene PDIA4 and cancer.