SIRPA and cancer: Koh et al. [90] found that exosomes from SIRPα variant-transfected HEK293T cells enhanced the phagocytosis of CT26.CL25 and HT29 tumor cells by macrophages and enhanced T-cell infiltration via antagonizing the interaction between CD47 and SIRPα, thereby inhibiting the growth of cancer in syngeneic mice models.