HDAC10 and colorectal cancer: Although DKFZ-748 was again slightly more effective than DKFZ-728, the results with both inhibitors were comparable to those of HDAC10KO cells, further confirming that pharmacologically inhibiting HDAC10 activity reproduces the phenotype observed with its genetic elimination in colorectal cancer cells and that HDAC10 is the sole enzyme responsible for deacetylating N8-AcSpd.