In addition, inhibition of Cdc20-APC/C-securin signaling, through a mechanism that does not rely on the p53-dependent downregulation of Cdc20, may be a valid approach to induce/enhance cell death in NSCLC cells carrying mutant p53, in which chemotherapeutic drugs fail to downregulate Cdc20 in the absence of WT p53. The gene discussed is PTTG1; the disease is non-small cell lung carcinoma.