Although it requires to clarify the types of cells expressing T1R3 in the sinonasal mucosa, these findings thus suggest a potential role of T1R3 in the pathophysiology of CRS, and the clinical relevance of its modulation by STR agonists, likely in patients with CRS unrelated to bacterial rhinosinusitis, awaits further study. The gene discussed is TAS1R3; the disease is congenital rubella syndrome.