We were the first to establish the TAMs‐lung cancer cell spheroids (M2/LLC spheroids) by incubating the M2‐like macrophages with LLC cells (Figure 5A), followed by the verification using antibodies against TTF1 (the marker for LLC cells) and CD206 (the marker for TAMs) by immunofluorescence staining (Figure 5B). This evidence concerns the gene MRC1 and lung cancer.