HBEC express HLA‐G, which immunotolerant properties have been extensively shown: HLA‐G modulates NK‐ and cytotoxic T‐lymphocyte (CTL)‐mediated activity through interaction with their inhibitory receptors23, 24, 25, 26 and its role in lung inflammation control has been supported in lung transplant studies with higher expression in stable recipients than in those with acute rejection or Bronchiolitis Obliterans Syndrome (BOS)24 or lower expression associated to de novo Donor Specific Antibody (DSA).27 This evidence concerns the gene HLA-G and Buschke-Ollendorff syndrome.