Our study supported that HLA‐F is expressed at cell surface in asthmatic context in both PLT and HBEC cells, however we did not explore mechanistic insights concerning HLA‐F mobilisation at cell surface or HLA‐F conformation expression; studies are also needed to investigate the association of HLA‐F expression according to the magnitude of inflammation i.e. asthma severity and other lung disease (COPD, CF and non‐CF bronchiectasis). Here, HLA-F is linked to asthma.