In particular, we found proteins involved in the regulation of pathways aberrantly activated in mesothelioma, such as MAPK, PI3K-Akt and mTOR signalling pathways [4, 11, 12], as well as the EGFR [13], Hippo [14, 15], epithelial to mesenchymal transition [16] and NF-kappa B signalling pathways [17, 18]. This evidence concerns the gene AKT1 and mesothelioma.