Our results in humans might correspond with the observations in animals that VEGFb transgenic overexpression or adipose VEGFb protein delivery alleviate MS, stimulate fat burning and diminish obesity by enhancing the activation of VEGFR2 signaling pathways and thermogenesis [21, 22], effects which are similar to those of physical exercise. Here, KDR is linked to obesity due to melanocortin 4 receptor deficiency.