The therapeutics effect of IMQ against AK and cutaneous malignancies like BCC is chiefly governed by the cytotoxic CD8+ T-cells which were activated by optimal stimulation of TLR-7 mediated MyD88 dependent NF-κβ activation (non-constitutive NF-κβ production) and IFN-γ9,10,57,82. The gene discussed is CD8A; the disease is skin basal cell carcinoma.