As an example, the most significant pathway detected by PANTHER is a toll-like receptor signaling pathway for co-cluster 111 comprised of hypothyroidism/myxedema and levothyroxine sodium medication, and genes TLR1, TLR6, and TLR10 in the cells—EBV-transformed lymphocytes tissue (Fig. 3a, Table 1, and Supplementary Fig. 5). Here, TLR6 is linked to hypothyroidism.